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by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs uses Obitrap Fusion Lumos mass analyzer system for high quality and efficient protein PTMs ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs offers protein analysis serivce, based on sophisticated mass spectrometry ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs uses GC/MS and UPLC/TripleQuad5500 platforms for analyzing carbohydrates and glycolysis pathway metabolites, with high accuracy, specificity, and sensitivity. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The term "Proteomics" is the combination of "protein" and "genomics", referring to the full set of proteins expressed by a genome, which consists of all the proteins expressed by a cell or an organism. In 1995 (though there are mentions of 1994 and 1996), Marc Wilkins first proposed the concept of proteome, and in 1997, Peter James (who worked at the Swiss Federal Institute of Technology, known ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
S-nitrosylation (SNO) is the covalent attachment of some nitroso (NO) groups to sulfhydryl residues (S) in proteins, forming S-nitrosothiols (SNOs). These groups are subsets of specific cysteine residues, leading to the formation of S-nitrosylated proteins. SNOs have a short half-life in the cytosol due to various reductases, such as glutathione (GSH) and thioredoxin, which act to remove the ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs provides comprehensive protein sequencing services to meet various needs of our ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Glycosylation has significant impacts on the efficacy, stability, and immunogenicity of biopharmaceuticals. Among these, the oligosaccharide spectrum and glycan structure are important indicators for assessing the characteristics of biopharmaceuticals. Oligosaccharides, as important carbohydrates, participate in various cellular life processes, such as protein folding and signal transduction. In ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
In recent years, with the progress in the field of drug discovery, circular dichroism (CD) has become one of the core technologies for protein and peptide drug development and research. Circular dichrographic scanning analysis of proteins and peptides is of great significance for studying their secondary and advanced structures. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The sample preparation process encompasses: (1) releasing DNA from samples and cells through lysis, (2) isolating DNA, (3) purifying DNA by removing inhibitory substances, and (4) optionally, concentrating DNA, which is critical for detecting low-concentration ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Due to significant developments in mass spectrometry (MS) technology and software, quantitative proteomic analysis has become the primary method for protein quantification. This technique is mainly based on bottom-up (shotgun) proteomics, which relies on the analysis of proteins digested by proteases in biological samples. Depending on the study, optional enrichment of organelles, modifications, ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
As the main components of cell membranes and energy sources, lipids play a significant role in both cellular and physiological energy homeostasis. The primary biological functions of lipids include energy storage, signal transduction, and serving as structural components of cell membranes. The composition of lipids varies among different tissues. In animal tissues, the composition of structural ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The amino acid sequence of proteins forms the basis for determining protein structure and function. Protein sequencing, which determines the types and arrangement of amino acids composing a protein, is a crucial aspect of proteomic studies. Common methods include mass spectrometry (such as tandem mass spectrometry) and the Edman degradation method. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Unknown protein identification refers to the process of identifying, studying, and annotating proteins that are not fully understood in terms of function and structure. This process mainly includes protein molecular weight determination, amino acid sequence determination, structure prediction, functional analysis, and interaction network analysis. Mass spectrometry technology is an important ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) is frequently employed in protein expression analysis and other scientific research endeavors. It facilitates obtaining electrophoretic profiles of protein samples, which, when combined with mass spectrometry-based protein identification services, allows for analysis or purification of samples, particularly for proteomic ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The label transfer method, in conjunction with crosslinking, facilitates the study of protein interactions by marking proteins that bind to target proteins. This technique is invaluable for discovering new interactions, validating proteins identified by other methods, and analyzing protein complexes. It is particularly effective for detecting weak and transient interactions, which often elude ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Protein secondary structure analysis refers to the study of local spatial structures between continuous amino acid residues in proteins, mainly including α-helix, β-sheet, and others. Understanding protein secondary structures helps reveal their folding mechanisms, stability, function, and interactions with other biomolecules, providing important information for studying the biological functions ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Dynamic light scattering (DLS), also known as photon correlation spectroscopy (PCS) or quasi-elastic light scattering (QELS), is a prevalent analytical technique for determining particle sizes and distribution in suspensions or polymer ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Mass spectrometry-based sequence analysis of proteins, antibodies, peptides, and other samples involves the analysis of the sample's amino acid sequence. Mass spectrometry sequencing refers to the determination of the primary structure of amino acid sequences based on mass spectrometry. Before moving on to mass spectrometry sequence analysis, we provide a brief introduction to a few ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
AQUA absolute quantitative analysis is a targeted quantitative proteomics technique widely used in various quantitative proteomics studies. The absolute quantification strategy can be used for the absolute quantification of proteins and their modified ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Peptides are abundant in living organisms, actively participating in key biological processes such as hormone regulation, enzyme catalysis, and immune responses. Their spatial structure and functional features greatly influence their biological activity. Accurately determining peptide structures is essential for understanding peptide folding patterns, bioactivity, and structural features. It also ...